JJAP Conference Proceedings

JJAP Conf. Proc. 4, 011301 (2016) doi:10.7567/JJAPCP.4.011301

Novel molecular targeted and wide spectrum antitumor agents: Preparation and preclinical evaluation of IER5/Cdc25B targeted low-molecular-weight phospha sugar derivatives

Hiroko Hasegawa1, Mitsuji Yamashita1, Reiko Makita1, Mayumi Yamaoka1, Michio Fujie2, Satoki Nakamura2, Tatsuo Oshikawa3, Junko Yamashita1, Manabu Yamada1, Mitsuru Kondo1, Kazutaka Hirakawa1, Mitsuo Toda1, Yasuo Takehara2, Kazunori Ohnishi2, Haruhiko Sugimura2, Sophie Laurent4, Robert N. Muller4

  1. 1Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan
  2. 2Faculty of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
  3. 3Department of Chemistry and Biochemistry, Numazu National College of Technology, Numazu,Shizuoka 410-8501, Japan
  4. 4Faculty of Medicine, University of Mons, Mons, Hainaut, Belgium
  • Received October 10, 2015
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Abstract

Novel broad spectrum low-molecular-weight antitumor agents of phospha sugar derivatives were investigated and developed. Branched deoxybromophospha sugars, such as DBMPP and TBMPP, which target IER5/Cdc25B and innovate in chemo-therapeutic treatments against various type of cancer cells. These successful preclinical in vitro and in vivo evaluations observed might be expected to afford clinically useful drugs and innovative medical treatments for various kinds of cancers.

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